The USinfo-icon has dropped the "mother of all bombs" - the largest non-nuclear weapon ever used in combat by the US military - on an area of eastern Afghanistaninfo-icon known to be populated by Isis-affiliated militants.

A GBU-43/B Massive Ordnance Air Blast Bomb (MOAB), also known as the "mother of all bombs," was dropped at 7:32 pm local time Thursday, the Pentagon said.The Pentagon confirmed the strike was the first time the enormous bomb had been used in combat.

The MOAB weighs about 22,000 pounds (10,000 kg) and is the most powerful non-nuclear weapon ever designed. It was developed during the US warinfo-icon on Iraqinfo-icon and is intended to target large below-surface areas.

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The bomb was dropped on ISIL tunnels in Nangarhar province by an MC-130 aircraft, operated by US Air Force Special Operations Command, according to the Pentagon.Military experts say the blast would "feel like a nuclear weapon to anyone near the area."

The "Air Force must have had a good target...normally smaller artillery could have been used," retired US Armyinfo-icon General Mark Hertling told CNN."As (ISIL-Khorasan's) losses have mounted, they are using IEDs, bunkers and tunnels to thicken their defense," said General John Nicholson, who heads US Forces Afghanistan.

"This is the right munition to reduce these obstacles and maintain the momentum of our offensive against ISIL-K," he added.

ISIL is suspected of carrying out several attacks against Shias in Afghanistan. According to the US intelligence, the Takfiri terrorist group is mostly active in Nangarhar and its neighboring Kunar province. There are thought to be between 700 to 1,500 Daesh members operating in the country.

Afghanistan is still suffering from insecurity and violence years after the United Statesinfo-icon and its allies invaded the country as part of Washington's so-called war on terror. The military invasion removed the Taliban from power, but their militancy continues to this day.

ISIL strengthEstimates of ISIL's strength in Afghanistan vary.

US officials have said they believe the group has only 700 fighters, but Afghan officials estimate there are closer to 1,500 in the country.

Western and Afghan security officials believe fighters frequently switch allegiances between armed groups, making it difficult to know who is to blame for violence.Peter Galbraith, a former US diplomat and former UN deputy special representative for Afghanistan, said ISIL would have to be targeted in different locations for the US military strategy to succeed.

"ISIL doesn't concentrate its forces ... so you have to target it in many different places," he told reporters. He said conditions for military operations in ISIL's Syrian and Iraqi strongholds, Raqqa and Mosulinfo-icon, are different, as they are urban areas with civilian populations.

"A bomb of this magnitude could cause a lot of collateral damage," Galbraith said.

"But when you're using it in a remote, rural part of Nangarhar province in Afghanistan, you presumably can have some confidence that you'll not have civilian casualties, or at least not many of them."